Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 4.023


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog
FOSB 2354 FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 8061 FOS-like antigen 1
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOSL1chr11_-_656678090.894.0e-06Click!
JUNDchr19_-_18392436-0.458.0e-02Click!
FOSchr14_+_757454800.421.1e-01Click!
FOSBchr19_+_459712490.332.1e-01Click!
JUNBchr19_+_129022950.068.3e-01Click!


Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_21452981 36.591 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr1_+_183155393 24.976 LAMC2
laminin, gamma 2
chr12_+_13349601 24.247 NM_001423
EMP1
epithelial membrane protein 1
chr12_+_13349720 21.920 EMP1
epithelial membrane protein 1
chr1_+_223889253 21.602 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr1_+_153003677 19.540 NM_003125
SPRR1B
small proline-rich protein 1B
chr1_+_183155173 18.400 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr1_+_183155361 17.009 LAMC2
laminin, gamma 2
chr12_-_52886971 15.520 NM_005554
KRT6A
keratin 6A
chr18_+_61442611 15.419 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr3_-_151034514 15.282 NM_023915
GPR87
G protein-coupled receptor 87
chr19_-_39264144 15.211 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr1_-_95007139 15.101 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr17_-_39768939 13.968 NM_005557
KRT16
keratin 16
chr1_-_209824641 13.872 NM_001017402
LAMB3
laminin, beta 3
chr3_-_149095413 12.095 TM4SF1
transmembrane 4 L six family member 1
chr6_+_83072922 11.790 NM_006670
TPBG
trophoblast glycoprotein
chr2_-_216259197 11.418 FN1
fibronectin 1
chr3_-_149095517 11.258 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr3_-_149095458 11.151 TM4SF1
transmembrane 4 L six family member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 24 entries
Enrichment   P-value GO Accession GO Term
28.87 2.11e-05 GO:0031581 hemidesmosome assembly
14.44 2.86e-03 GO:0031424 keratinization
13.23 7.67e-04 GO:0007044 cell-substrate junction assembly
8.42 1.92e-02 GO:0030216 keratinocyte differentiation
7.56 1.08e-02 GO:0010951 negative regulation of endopeptidase activity
7.47 1.85e-10 GO:0008544 epidermis development
6.27 1.44e-02 GO:0031099 regeneration
5.61 3.60e-02 GO:0010466 negative regulation of peptidase activity
4.82 4.97e-02 GO:0030162 regulation of proteolysis
3.64 1.39e-11 GO:0009888 tissue development
3.45 3.22e-03 GO:0060429 epithelium development
2.85 9.91e-05 GO:0007155 cell adhesion
2.85 9.91e-05 GO:0022610 biological adhesion
2.74 3.61e-03 GO:0042060 wound healing
2.45 8.86e-04 GO:0009611 response to wounding
2.14 4.33e-02 GO:0042127 regulation of cell proliferation
2.06 4.91e-05 GO:0048513 organ development
1.80 1.03e-05 GO:0048856 anatomical structure development
1.80 6.72e-05 GO:0048731 system development
1.79 2.26e-02 GO:0030154 cell differentiation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 20 entries
Enrichment   P-value GO Accession GO Term
23.52 3.09e-03 GO:0043256 laminin complex
21.79 2.76e-06 GO:0001533 cornified envelope
14.12 3.06e-02 GO:0005605 basal lamina
6.39 2.21e-02 GO:0005604 basement membrane
5.96 4.04e-03 GO:0005882 intermediate filament
5.79 4.15e-02 GO:0016327 apicolateral plasma membrane
5.40 3.32e-03 GO:0044420 extracellular matrix part
5.24 4.34e-03 GO:0045111 intermediate filament cytoskeleton
5.04 1.53e-04 GO:0070161 anchoring junction
4.66 3.95e-04 GO:0005911 cell-cell junction
4.41 8.54e-03 GO:0005912 adherens junction
4.11 4.12e-05 GO:0005578 proteinaceous extracellular matrix
3.76 4.15e-05 GO:0031012 extracellular matrix
3.04 9.31e-05 GO:0030054 cell junction
2.15 3.85e-03 GO:0044421 extracellular region part
1.90 9.02e-03 GO:0005856 cytoskeleton
1.79 9.38e-03 GO:0005576 extracellular region
1.74 2.10e-03 GO:0044459 plasma membrane part
1.64 2.85e-05 GO:0005886 plasma membrane
1.62 5.84e-05 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
Enrichment   P-value GO Accession GO Term
8.54 5.20e-05 GO:0004867 serine-type endopeptidase inhibitor activity
5.62 3.43e-04 GO:0004866 endopeptidase inhibitor activity
5.53 4.14e-04 GO:0030414 peptidase inhibitor activity
5.39 5.44e-04 GO:0061135 endopeptidase regulator activity
4.45 4.00e-03 GO:0061134 peptidase regulator activity
2.72 8.31e-04 GO:0005198 structural molecule activity